Important note

Mutalyzer 2 is no longer supported and access to it will be provided only for a limited amount of time.

Please switch to Mutalyzer 3 !

About Mutalyzer

Contact

The Mutalyzer mailing list is a general discussion list for Mutalyzer. Messages can be posted to this list via the Google Groups interface or by sending an email to mutalyzer@googlegroups.com.

Open Source

Mutalyzer is Open Source and available under the GNU Affero General Public License.

Mutalyzer source code is available on GitHub: github.com/mutalyzer/mutalyzer2

If you're interested in running your own Mutalyzer installation, please have a look at our Mutalyzer Ansible role for a completely automated deployment.

Development

Mutalyzer 2.0.35 is designed and developed by Jeroen F.J. Laros, with the following exceptions:

  • The LRG parser, as well as the Batch interfaces are written by Gerben R. Stouten.
  • The position converter interfaces (web service and WWW) are written by Gerard C.P. Schaafsma.
  • Current development and maintenance is done by Martijn Vermaat.
  • Automatic extraction of variant descriptions is implemented by Jonathan Vis.

Furthermore we would like to thank the following people for their valuable work on previous versions that acted as a guideline for the development of the current version:

  • Ernest van Ophuizen.
  • Martin Wildeman.
  • Corinne Bareil.
  • Gerben R. Stouten.

Specifications are given by Peter E.M. Taschner and Johan T. den Dunnen.

Please mention "Lefter M et al. (2021). Mutalyzer 2: Next Generation HGVS Nomenclature Checker. Bioinformatics, btab051" (direct link) when referring to these pages.

The Description Extractor is described separately in "Vis JK et al. (2015). An efficient algorithm for the extraction of HGVS variant descriptions from sequences. Bioinformatics, 2015 Dec 1;31(23):3751-7" (direct link).

We thank the following organisations for their contribution to the development of Mutalyzer.

Gen2Phen Netherlands Bioinformatics Centre EuroGentest Dutch national program COMMIT Landscape - Increasing Data Impact SUN Microsystems
HVP IRDiRC

Counters

We keep simple counters for the use of the various Mutalyzer services, broken down by interface.

Service Interface Total (all interfaces)
Website Webservice Batch job
Syntax checker 69,451 9,185,252 3,818,538 13,073,241
Name checker 35,362,926 63,718,549 110,867,310 209,948,785
Description extractor 129,412 28,140,958 N/A 28,270,370
Position converter 31,530,300 124,287,911 246,596,787 402,414,998
SNP converter 582,367 4,302,805 35,135,713 40,020,885
Batch jobs 128,533 249,769 N/A 378,302
Total (all services) 67,802,989 229,885,244 396,418,348 694,106,581