LOCUS NM_000038 10740 bp mRNA linear PRI 17-NOV-2018 DEFINITION Homo sapiens APC, WNT signaling pathway regulator (APC), transcript variant 3, mRNA. ACCESSION NM_000038 VERSION NM_000038.5 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 10740) AUTHORS Sundell GN, Arnold R, Ali M, Naksukpaiboon P, Orts J, Guntert P, Chi CN and Ivarsson Y. TITLE Proteome-wide analysis of phospho-regulated PDZ domain interactions JOURNAL Mol. Syst. Biol. 14 (8), e8129 (2018) PUBMED 30126976 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 10740) AUTHORS Yokota T, Serizawa M, Hosokawa A, Kusafuka K, Mori K, Sugiyama T, Tsubosa Y and Koh Y. TITLE PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue JOURNAL BMC Cancer 18 (1), 826 (2018) PUBMED 30115035 REMARK GeneRIF: Multivariate analyses revealed that the PIK3CA mutation and clinical T stage were independent favorable prognostic factors (hazard ratio 0.34, 95% confidence interval: 0.12-0.96, p = 0.042). PIK3CA mutations were significantly associated with APC alterations (p = 0.0007) and BRAF mutations (p = 0.0090). Publication Status: Online-Only REFERENCE 3 (bases 1 to 10740) AUTHORS Wang Y, Cao C, Fang D and Hu Y. TITLE Role of APC-mediated MDR-1/CLCX-1 signaling pathway in ovarian tumors JOURNAL J. Biol. Regul. Homeost. Agents 32 (3), 529-536 (2018) PUBMED 29921377 REMARK GeneRIF: There is a certain correlation between the APC gene and ovarian tumors, and the APC gene mediates the apoptosis of tumor cells through the MDR-1/CLCX-1 signaling pathway. REFERENCE 4 (bases 1 to 10740) AUTHORS Lambertz S and Ballhausen WG. TITLE Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene JOURNAL Hum. Genet. 90 (6), 650-652 (1993) PUBMED 8383094 REFERENCE 5 (bases 1 to 10740) AUTHORS Jasperson,K.W., Patel,S.G. and Ahnen,D.J. TITLE APC-Associated Polyposis Conditions JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K and Amemiya A (Eds.); GENEREVIEWS((R)); (1993) PUBMED 20301519 REFERENCE 6 (bases 1 to 10740) AUTHORS Nakatsuru S, Yanagisawa A, Ichii S, Tahara E, Kato Y, Nakamura Y and Horii A. TITLE Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma JOURNAL Hum. Mol. Genet. 1 (8), 559-563 (1992) PUBMED 1338691 REFERENCE 7 (bases 1 to 10740) AUTHORS Miki Y, Nishisho I, Horii A, Miyoshi Y, Utsunomiya J, Kinzler KW, Vogelstein B and Nakamura Y. TITLE Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer JOURNAL Cancer Res. 52 (3), 643-645 (1992) PUBMED 1310068 REFERENCE 8 (bases 1 to 10740) AUTHORS Nagase H, Miyoshi Y, Horii A, Aoki T, Petersen GM, Vogelstein B, Maher E, Ogawa M, Maruyama M, Utsunomiya J et al. TITLE Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients JOURNAL Hum. Mutat. 1 (6), 467-473 (1992) PUBMED 1338764 REFERENCE 9 (bases 1 to 10740) AUTHORS Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S and Hedge P. TITLE Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients JOURNAL Science 253 (5020), 665-669 (1991) PUBMED 1651563 REFERENCE 10 (bases 1 to 10740) AUTHORS Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D et al. TITLE Identification of FAP locus genes from chromosome 5q21 JOURNAL Science 253 (5020), 661-665 (1991) PUBMED 1651562 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA795663.1, M73548.1, AB210001.1 and CA313732.1. [WARNING] On Nov 22, 2018 this sequence was replaced by NM_000038.6. On Sep 17, 2010 this sequence version replaced NM_000038.4. Summary: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.217786.1, M73548.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-66 DA795663.1 1-66 67-634 M73548.1 20-587 635-10547 AB210001.1 707-10619 10548-10740 CA313732.1 8-200 c FEATURES Location/Qualifiers source 1..10740 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5q22.2" gene 1..10740 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /note="APC, WNT signaling pathway regulator" /db_xref="GeneID:324" /db_xref="HGNC:HGNC:583" /db_xref="MIM:611731" exon 1..67 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 68..220 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" misc_feature 77..79 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /note="upstream in-frame stop codon" CDS 86..8617 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /note="isoform b is encoded by transcript variant 3; adenomatous polyposis coli protein; WNT signaling pathway regulator; adenomatosis polyposis coli tumor suppressor; deleted in polyposis 2.5; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; adenomatous polyposis coli (APC); epididymis secretory sperm binding protein" /codon_start=1 /product="adenomatous polyposis coli protein isoform b" /protein_id="NP_000029.2" /db_xref="CCDS:CCDS4107.1" /db_xref="GeneID:324" /db_xref="HGNC:HGNC:583" /db_xref="MIM:611731" /translation="MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNM KEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGS VSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYA QLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRI ARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGN GQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTL LAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIH SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNL TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREV GSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRS QTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACG TLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDA NIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGD YVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERER GIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHC VTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDG YGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLK YSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLK FQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSER YSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQ SSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTY CVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPV SEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQ ETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRS KTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATE STPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKE AEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPS QLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNE LAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAE CINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTE YRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDS PHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTEL TSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIEN TPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVED TPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGE DLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDS DSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKG GKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSK KGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRD STPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKM SYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSST KSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQ TPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSR LPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSIS GTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKT EDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVP MRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKH SSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGT QSPKRHSGSYLVTSV" misc_feature 89..91 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="N-acetylalanine. {ECO:0000244|PubMed:22814378}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 404..406 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 416..418 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 1442..1570 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 1" misc_feature 1598..1726 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 2" misc_feature 1727..1858 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 3" misc_feature 1859..1999 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 4" misc_feature 2000..2134 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 5" misc_feature 2135..2260 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 6" misc_feature 2261..2386 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: ARM 7" misc_feature 2315..2317 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 2327..2329 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 2423..2425 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:24275569}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 2807..2809 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 2963..4096 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: Responsible for down-regulation through a process mediated by direct ubiquitination" misc_feature 3044..3046 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 3197..3199 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 3209..3211 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4163..4165 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4196..4198 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4238..4240 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4259..4261 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4268..4270 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4397..4399 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 4784..4786 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 5405..5407 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 5666..5668 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 5672..5674 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 5675..5677 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 5681..5764 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: Highly charged" misc_feature 5996..5998 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6002..6004 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6347..6349 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6362..6364 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6458..6460 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:Q61315}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6470..6472 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6473..6475 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6479..6481 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6536..6538 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine. {ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6863..6865 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6893..6895 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 6932..6934 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 7502..7504 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 7688..7690 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 7790..7792 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8096..8098 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18220336, ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8105..8107 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8120..8122 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine. {ECO:0000244|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8213..8215 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P70478}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8255..8257 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8450..8452 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (P25054.2); other site" misc_feature 8492..8503 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: Microtubule tip localization signal" misc_feature 8606..8614 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P25054.2); Region: PDZ-binding" exon 221..305 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 306..507 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 508..616 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 617..730 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 731..814 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 815..919 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 920..1018 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 1019..1397 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 1398..1493 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 1494..1633 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 1634..1711 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 1712..1828 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 1829..2043 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" exon 2044..10730 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" /inference="alignment:Splign:2.1.0" polyA_site 10730 /gene="APC" /gene_synonym="BTPS2; DP2; DP2.5; DP3; GS; PPP1R46" ORIGIN 1 gtattggtgc agcccgccag ggtgtcactg gagacagaat ggaggtgctg ccggactcgg 61 aaatggggtc caagggtagc caaggatggc tgcagcttca tatgatcagt tgttaaagca 121 agttgaggca ctgaagatgg agaactcaaa tcttcgacaa gagctagaag ataattccaa 181 tcatcttaca aaactggaaa ctgaggcatc taatatgaag gaagtactta aacaactaca 241 aggaagtatt gaagatgaag ctatggcttc ttctggacag attgatttat tagagcgtct 301 taaagagctt aacttagata gcagtaattt ccctggagta aaactgcggt caaaaatgtc 361 cctccgttct tatggaagcc gggaaggatc tgtatcaagc cgttctggag agtgcagtcc 421 tgttcctatg ggttcatttc caagaagagg gtttgtaaat ggaagcagag aaagtactgg 481 atatttagaa gaacttgaga aagagaggtc attgcttctt gctgatcttg acaaagaaga 541 aaaggaaaaa gactggtatt acgctcaact tcagaatctc actaaaagaa tagatagtct 601 tcctttaact gaaaattttt ccttacaaac agatatgacc agaaggcaat tggaatatga 661 agcaaggcaa atcagagttg cgatggaaga acaactaggt acctgccagg atatggaaaa 721 acgagcacag cgaagaatag ccagaattca gcaaatcgaa aaggacatac ttcgtatacg 781 acagctttta cagtcccaag caacagaagc agagaggtca tctcagaaca agcatgaaac 841 cggctcacat gatgctgagc ggcagaatga aggtcaagga gtgggagaaa tcaacatggc 901 aacttctggt aatggtcagg gttcaactac acgaatggac catgaaacag ccagtgtttt 961 gagttctagt agcacacact ctgcacctcg aaggctgaca agtcatctgg gaaccaaggt 1021 ggaaatggtg tattcattgt tgtcaatgct tggtactcat gataaggatg atatgtcgcg 1081 aactttgcta gctatgtcta gctcccaaga cagctgtata tccatgcgac agtctggatg 1141 tcttcctctc ctcatccagc ttttacatgg caatgacaaa gactctgtat tgttgggaaa 1201 ttcccggggc agtaaagagg ctcgggccag ggccagtgca gcactccaca acatcattca 1261 ctcacagcct gatgacaaga gaggcaggcg tgaaatccga gtccttcatc ttttggaaca 1321 gatacgcgct tactgtgaaa cctgttggga gtggcaggaa gctcatgaac caggcatgga 1381 ccaggacaaa aatccaatgc cagctcctgt tgaacatcag atctgtcctg ctgtgtgtgt 1441 tctaatgaaa ctttcatttg atgaagagca tagacatgca atgaatgaac tagggggact 1501 acaggccatt gcagaattat tgcaagtgga ctgtgaaatg tatgggctta ctaatgacca 1561 ctacagtatt acactaagac gatatgctgg aatggctttg acaaacttga cttttggaga 1621 tgtagccaac aaggctacgc tatgctctat gaaaggctgc atgagagcac ttgtggccca 1681 actaaaatct gaaagtgaag acttacagca ggttattgcg agtgttttga ggaatttgtc 1741 ttggcgagca gatgtaaata gtaaaaagac gttgcgagaa gttggaagtg tgaaagcatt 1801 gatggaatgt gctttagaag ttaaaaagga atcaaccctc aaaagcgtat tgagtgcctt 1861 atggaatttg tcagcacatt gcactgagaa taaagctgat atatgtgctg tagatggtgc 1921 acttgcattt ttggttggca ctcttactta ccggagccag acaaacactt tagccattat 1981 tgaaagtgga ggtgggatat tacggaatgt gtccagcttg atagctacaa atgaggacca 2041 caggcaaatc ctaagagaga acaactgtct acaaacttta ttacaacact taaaatctca 2101 tagtttgaca atagtcagta atgcatgtgg aactttgtgg aatctctcag caagaaatcc 2161 taaagaccag gaagcattat gggacatggg ggcagttagc atgctcaaga acctcattca 2221 ttcaaagcac aaaatgattg ctatgggaag tgctgcagct ttaaggaatc tcatggcaaa 2281 taggcctgcg aagtacaagg atgccaatat tatgtctcct ggctcaagct tgccatctct 2341 tcatgttagg aaacaaaaag ccctagaagc agaattagat gctcagcact tatcagaaac 2401 ttttgacaat atagacaatt taagtcccaa ggcatctcat cgtagtaagc agagacacaa 2461 gcaaagtctc tatggtgatt atgtttttga caccaatcga catgatgata ataggtcaga 2521 caattttaat actggcaaca tgactgtcct ttcaccatat ttgaatacta cagtgttacc 2581 cagctcctct tcatcaagag gaagcttaga tagttctcgt tctgaaaaag atagaagttt 2641 ggagagagaa cgcggaattg gtctaggcaa ctaccatcca gcaacagaaa atccaggaac 2701 ttcttcaaag cgaggtttgc agatctccac cactgcagcc cagattgcca aagtcatgga 2761 agaagtgtca gccattcata cctctcagga agacagaagt tctgggtcta ccactgaatt 2821 acattgtgtg acagatgaga gaaatgcact tagaagaagc tctgctgccc atacacattc 2881 aaacacttac aatttcacta agtcggaaaa ttcaaatagg acatgttcta tgccttatgc 2941 caaattagaa tacaagagat cttcaaatga tagtttaaat agtgtcagta gtagtgatgg 3001 ttatggtaaa agaggtcaaa tgaaaccctc gattgaatcc tattctgaag atgatgaaag 3061 taagttttgc agttatggtc aatacccagc cgacctagcc cataaaatac atagtgcaaa 3121 tcatatggat gataatgatg gagaactaga tacaccaata aattatagtc ttaaatattc 3181 agatgagcag ttgaactctg gaaggcaaag tccttcacag aatgaaagat gggcaagacc 3241 caaacacata atagaagatg aaataaaaca aagtgagcaa agacaatcaa ggaatcaaag 3301 tacaacttat cctgtttata ctgagagcac tgatgataaa cacctcaagt tccaaccaca 3361 ttttggacag caggaatgtg tttctccata caggtcacgg ggagccaatg gttcagaaac 3421 aaatcgagtg ggttctaatc atggaattaa tcaaaatgta agccagtctt tgtgtcaaga 3481 agatgactat gaagatgata agcctaccaa ttatagtgaa cgttactctg aagaagaaca 3541 gcatgaagaa gaagagagac caacaaatta tagcataaaa tataatgaag agaaacgtca 3601 tgtggatcag cctattgatt atagtttaaa atatgccaca gatattcctt catcacagaa 3661 acagtcattt tcattctcaa agagttcatc tggacaaagc agtaaaaccg aacatatgtc 3721 ttcaagcagt gagaatacgt ccacaccttc atctaatgcc aagaggcaga atcagctcca 3781 tccaagttct gcacagagta gaagtggtca gcctcaaaag gctgccactt gcaaagtttc 3841 ttctattaac caagaaacaa tacagactta ttgtgtagaa gatactccaa tatgtttttc 3901 aagatgtagt tcattatcat ctttgtcatc agctgaagat gaaataggat gtaatcagac 3961 gacacaggaa gcagattctg ctaataccct gcaaatagca gaaataaaag aaaagattgg 4021 aactaggtca gctgaagatc ctgtgagcga agttccagca gtgtcacagc accctagaac 4081 caaatccagc agactgcagg gttctagttt atcttcagaa tcagccaggc acaaagctgt 4141 tgaattttct tcaggagcga aatctccctc caaaagtggt gctcagacac ccaaaagtcc 4201 acctgaacac tatgttcagg agaccccact catgtttagc agatgtactt ctgtcagttc 4261 acttgatagt tttgagagtc gttcgattgc cagctccgtt cagagtgaac catgcagtgg 4321 aatggtaagt ggcattataa gccccagtga tcttccagat agccctggac aaaccatgcc 4381 accaagcaga agtaaaacac ctccaccacc tcctcaaaca gctcaaacca agcgagaagt 4441 acctaaaaat aaagcaccta ctgctgaaaa gagagagagt ggacctaagc aagctgcagt 4501 aaatgctgca gttcagaggg tccaggttct tccagatgct gatactttat tacattttgc 4561 cacggaaagt actccagatg gattttcttg ttcatccagc ctgagtgctc tgagcctcga 4621 tgagccattt atacagaaag atgtggaatt aagaataatg cctccagttc aggaaaatga 4681 caatgggaat gaaacagaat cagagcagcc taaagaatca aatgaaaacc aagagaaaga 4741 ggcagaaaaa actattgatt ctgaaaagga cctattagat gattcagatg atgatgatat 4801 tgaaatacta gaagaatgta ttatttctgc catgccaaca aagtcatcac gtaaagcaaa 4861 aaagccagcc cagactgctt caaaattacc tccacctgtg gcaaggaaac caagtcagct 4921 gcctgtgtac aaacttctac catcacaaaa caggttgcaa ccccaaaagc atgttagttt 4981 tacaccgggg gatgatatgc cacgggtgta ttgtgttgaa gggacaccta taaacttttc 5041 cacagctaca tctctaagtg atctaacaat cgaatcccct ccaaatgagt tagctgctgg 5101 agaaggagtt agaggagggg cacagtcagg tgaatttgaa aaacgagata ccattcctac 5161 agaaggcaga agtacagatg aggctcaagg aggaaaaacc tcatctgtaa ccatacctga 5221 attggatgac aataaagcag aggaaggtga tattcttgca gaatgcatta attctgctat 5281 gcccaaaggg aaaagtcaca agcctttccg tgtgaaaaag ataatggacc aggtccagca 5341 agcatctgcg tcttcttctg cacccaacaa aaatcagtta gatggtaaga aaaagaaacc 5401 aacttcacca gtaaaaccta taccacaaaa tactgaatat aggacacgtg taagaaaaaa 5461 tgcagactca aaaaataatt taaatgctga gagagttttc tcagacaaca aagattcaaa 5521 gaaacagaat ttgaaaaata attccaaggt cttcaatgat aagctcccaa ataatgaaga 5581 tagagtcaga ggaagttttg cttttgattc acctcatcat tacacgccta ttgaaggaac 5641 tccttactgt ttttcacgaa atgattcttt gagttctcta gattttgatg atgatgatgt 5701 tgacctttcc agggaaaagg ctgaattaag aaaggcaaaa gaaaataagg aatcagaggc 5761 taaagttacc agccacacag aactaacctc caaccaacaa tcagctaata agacacaagc 5821 tattgcaaag cagccaataa atcgaggtca gcctaaaccc atacttcaga aacaatccac 5881 ttttccccag tcatccaaag acataccaga cagaggggca gcaactgatg aaaagttaca 5941 gaattttgct attgaaaata ctccggtttg cttttctcat aattcctctc tgagttctct 6001 cagtgacatt gaccaagaaa acaacaataa agaaaatgaa cctatcaaag agactgagcc 6061 ccctgactca cagggagaac caagtaaacc tcaagcatca ggctatgctc ctaaatcatt 6121 tcatgttgaa gataccccag tttgtttctc aagaaacagt tctctcagtt ctcttagtat 6181 tgactctgaa gatgacctgt tgcaggaatg tataagctcc gcaatgccaa aaaagaaaaa 6241 gccttcaaga ctcaagggtg ataatgaaaa acatagtccc agaaatatgg gtggcatatt 6301 aggtgaagat ctgacacttg atttgaaaga tatacagaga ccagattcag aacatggtct 6361 atcccctgat tcagaaaatt ttgattggaa agctattcag gaaggtgcaa attccatagt 6421 aagtagttta catcaagctg ctgctgctgc atgtttatct agacaagctt cgtctgattc 6481 agattccatc ctttccctga aatcaggaat ctctctggga tcaccatttc atcttacacc 6541 tgatcaagaa gaaaaaccct ttacaagtaa taaaggccca cgaattctaa aaccagggga 6601 gaaaagtaca ttggaaacta aaaagataga atctgaaagt aaaggaatca aaggaggaaa 6661 aaaagtttat aaaagtttga ttactggaaa agttcgatct aattcagaaa tttcaggcca 6721 aatgaaacag ccccttcaag caaacatgcc ttcaatctct cgaggcagga caatgattca 6781 tattccagga gttcgaaata gctcctcaag tacaagtcct gtttctaaaa aaggcccacc 6841 ccttaagact ccagcctcca aaagccctag tgaaggtcaa acagccacca cttctcctag 6901 aggagccaag ccatctgtga aatcagaatt aagccctgtt gccaggcaga catcccaaat 6961 aggtgggtca agtaaagcac cttctagatc aggatctaga gattcgaccc cttcaagacc 7021 tgcccagcaa ccattaagta gacctataca gtctcctggc cgaaactcaa tttcccctgg 7081 tagaaatgga ataagtcctc ctaacaaatt atctcaactt ccaaggacat catcccctag 7141 tactgcttca actaagtcct caggttctgg aaaaatgtca tatacatctc caggtagaca 7201 gatgagccaa cagaacctta ccaaacaaac aggtttatcc aagaatgcca gtagtattcc 7261 aagaagtgag tctgcctcca aaggactaaa tcagatgaat aatggtaatg gagccaataa 7321 aaaggtagaa ctttctagaa tgtcttcaac taaatcaagt ggaagtgaat ctgatagatc 7381 agaaagacct gtattagtac gccagtcaac tttcatcaaa gaagctccaa gcccaacctt 7441 aagaagaaaa ttggaggaat ctgcttcatt tgaatctctt tctccatcat ctagaccagc 7501 ttctcccact aggtcccagg cacaaactcc agttttaagt ccttcccttc ctgatatgtc 7561 tctatccaca cattcgtctg ttcaggctgg tggatggcga aaactcccac ctaatctcag 7621 tcccactata gagtataatg atggaagacc agcaaagcgc catgatattg cacggtctca 7681 ttctgaaagt ccttctagac ttccaatcaa taggtcagga acctggaaac gtgagcacag 7741 caaacattca tcatcccttc ctcgagtaag cacttggaga agaactggaa gttcatcttc 7801 aattctttct gcttcatcag aatccagtga aaaagcaaaa agtgaggatg aaaaacatgt 7861 gaactctatt tcaggaacca aacaaagtaa agaaaaccaa gtatccgcaa aaggaacatg 7921 gagaaaaata aaagaaaatg aattttctcc cacaaatagt acttctcaga ccgtttcctc 7981 aggtgctaca aatggtgctg aatcaaagac tctaatttat caaatggcac ctgctgtttc 8041 taaaacagag gatgtttggg tgagaattga ggactgtccc attaacaatc ctagatctgg 8101 aagatctccc acaggtaata ctcccccggt gattgacagt gtttcagaaa aggcaaatcc 8161 aaacattaaa gattcaaaag ataatcaggc aaaacaaaat gtgggtaatg gcagtgttcc 8221 catgcgtacc gtgggtttgg aaaatcgcct gaactccttt attcaggtgg atgcccctga 8281 ccaaaaagga actgagataa aaccaggaca aaataatcct gtccctgtat cagagactaa 8341 tgaaagttct atagtggaac gtaccccatt cagttctagc agctcaagca aacacagttc 8401 acctagtggg actgttgctg ccagagtgac tccttttaat tacaacccaa gccctaggaa 8461 aagcagcgca gatagcactt cagctcggcc atctcagatc ccaactccag tgaataacaa 8521 cacaaagaag cgagattcca aaactgacag cacagaatcc agtggaaccc aaagtcctaa 8581 gcgccattct gggtcttacc ttgtgacatc tgtttaaaag agaggaagaa tgaaactaag 8641 aaaattctat gttaattaca actgctatat agacattttg tttcaaatga aactttaaaa 8701 gactgaaaaa ttttgtaaat aggtttgatt cttgttagag ggtttttgtt ctggaagcca 8761 tatttgatag tatactttgt cttcactggt cttattttgg gaggcactct tgatggttag 8821 gaaaaaaata gtaaagccaa gtatgtttgt acagtatgtt ttacatgtat ttaaagtagc 8881 atcccatccc aacttccttt aattattgct tgtcttaaaa taatgaacac tacagataga 8941 aaatatgata tattgctgtt atcaatcatt tctagattat aaactgacta aacttacatc 9001 agggaaaaat tggtatttat gcaaaaaaaa atgtttttgt ccttgtgagt ccatctaaca 9061 tcataattaa tcatgtggct gtgaaattca cagtaatatg gttcccgatg aacaagttta 9121 cccagcctgc tttgctttac tgcatgaatg aaactgatgg ttcaatttca gaagtaatga 9181 ttaacagtta tgtggtcaca tgatgtgcat agagatagct acagtgtaat aatttacact 9241 attttgtgct ccaaacaaaa caaaaatctg tgtaactgta aaacattgaa tgaaactatt 9301 ttacctgaac tagattttat ctgaaagtag gtagaatttt tgctatgctg taatttgttg 9361 tatattctgg tatttgaggt gagatggctg ctcttttatt aatgagacat gaattgtgtc 9421 tcaacagaaa ctaaatgaac atttcagaat aaattattgc tgtatgtaaa ctgttactga 9481 aattggtatt tgtttgaagg gtcttgtttc acatttgtat taataattgt ttaaaatgcc 9541 tcttttaaaa gcttatataa atttttttct tcagcttcta tgcattaaga gtaaaattcc 9601 tcttactgta ataaaaacaa ttgaagaaga ctgttgccac ttaaccattc catgcgttgg 9661 cacttatcta ttcctgaaat ttcttttatg tgattagctc atcttgattt ttaatatttt 9721 tccacttaaa cttttttttc ttactccact ggagctcagt aaaagtaaat tcatgtaata 9781 gcaatgcaag cagcctagca cagactaagc attgagcata ataggcccac ataatttcct 9841 ctttcttaat attatagaat tctgtacttg aaattgattc ttagacattg cagtctcttc 9901 gaggctttac agtgtaaact gtcttgcccc ttcatcttct tgttgcaact gggtctgaca 9961 tgaacacttt ttatcaccct gtatgttagg gcaagatctc agcagtgaag tataatcagc 10021 actttgccat gctcagaaaa ttcaaatcac atggaacttt agaggtagat ttaatacgat 10081 taagatattc agaagtatat tttagaatcc ctgcctgtta aggaaacttt atttgtggta 10141 ggtacagttc tggggtacat gttaagtgtc cccttataca gtggagggaa gtcttccttc 10201 ctgaaggaaa ataaactgac acttattaac taagataatt tacttaatat atcttccctg 10261 atttgtttta aaagatcaga gggtgactga tgatacatgc atacatattt gttgaataaa 10321 tgaaaattta tttttagtga taagattcat acactctgta tttggggagg gaaaaccttt 10381 ttaagcatgg tggggcactc agataggagt gaatacacct acctggtgcc ttgaaaatca 10441 catcaagtag ttaattatct accccttacc tgtgtttata acttccaggt aatgagaatg 10501 atttttttta aagctaaaat gccagtaaat aaaagtgcta tgacttgagc taagatattt 10561 gactccaatg cctgtactgt gtctactgca ccactttgta aacacttcaa tttactatct 10621 ttgaaatgat tgacctttaa atttttgcca aatgttatct gaaattgtct atgaatacca 10681 tctacttctg ttgttttccc aggcttccat aaacaatgga gatacatgca aaaaaaaaaa //